| Round 1 |
| Saturday, 28 September 2019 |
| 1 | Old Bedians 2nd XV | 5 | 20 | Didsbury Toc H 3rd XV |
| 2 | Ashton-on-Mersey | v | Bye |
| 3 | Hope Valley | v | Bye |
| 4 | Stockport 3rd XV | v | Bye |
| 5 | Burnage 3rd XV | v | Bye |
| 6 | Wythenshawe | v | Bye |
| 7 | Macclesfield 4th XV | v | Bye |
| 8 | Bowdon 3rd XV | 36 | 19 | Ashton-Under-Lyne 2nd XV |
| 9 | Glossop 3rd XV | v | Bye |
| 10 | Crewe & Nantwich 3rd XV | v | Bye |
| 11 | Ormskirk 2nd XV | v | Bye |
| 12 | Clitheroe 2nd XV | v | Bye |
| 13 | Hawcoat Park 'A' Team (2nd XV) | v | Bye |
| 14 | Fylde Vandals (4th XV) | v | Bye |
| 15 | Lostock | v | Bye |
| 16 | Littleborough 3rd XV | v | Bye |
| 17 | Vale of Lune 3rd XV | v | Bye |
| 18 | Leigh 3rd XV | v | Bye |
| 19 | Preston Grasshoppers 4th XV | v | Bye |
| 20 | Rossendale 3rd XV | v | Bye |
| 21 | Blackburn 3rd XV | v | Bye |
| 22 | Tarleton 3rd XV | v | Bye |
| 23 | Wallasey | v | Bye |
| 24 | Widnes 3rd XV | v | Bye |
| 25 | Congleton 2nd XV | v | Bye |
| 26 | Hoylake 2nd XV | Home Walkover | Liverpool St Helens 3rd XV |
| 27 | Oswestry 2nd XV | v | Bye |
| 28 | Northwich 3rd XV | 17 | 55 | Christleton |
| 29 | West Park (St Helens) 3rd XV | v | Bye |
| 30 | Eagle | 13 | 3 | Oldershaw |
| 31 | Ellesmere Port 2nd XV | v | Bye |
| 32 | Prenton | v | Bye |
| Round 2 |
| Saturday, 12 October 2019 |
| Ormskirk 2nd XV | 86 | 10 | Clitheroe 2nd XV |
| Saturday, 26 October 2019 |
| Hope Valley | Home Walkover | Stockport 3rd XV |
| Macclesfield 4th XV | Home Walkover | Bowdon 3rd XV |
| Glossop 3rd XV | Home Walkover | Crewe & Nantwich 3rd XV |
| Hawcoat Park 'A' Team (2nd XV) | 42 | 10 | Fylde Vandals (4th XV) |
| Lostock | 57 | 0 | Littleborough 3rd XV |
| Vale of Lune 3rd XV | 11 | 11 | Leigh 3rd XV |
| Preston Grasshoppers 4th XV | Home Walkover | Rossendale 3rd XV |
| Saturday, 9 November 2019 |
| Blackburn 3rd XV | v | Bye |
| Wallasey | Home Walkover | Widnes 3rd XV |
| Congleton 2nd XV | 17 | 67 | Hoylake 2nd XV |
| West Park (St Helens) 3rd XV | 0 | 29 | Eagle |
| Ellesmere Port 2nd XV | 0 | 41 | Prenton |
| Saturday, 16 November 2019 |
| Ashton-on-Mersey | 30 | 5 | Didsbury Toc H 3rd XV |
| Tuesday, 19 November 2019 |
| Burnage 3rd XV | Home Walkover | Wythenshawe |
| Saturday, 21 December 2019 |
| Oswestry 2nd XV | 64 | 7 | Christleton |
| Round 3 |
| Saturday, 18 January 2020 |
| Hawcoat Park 'A' Team (2nd XV) | 5 | 22 | Lostock |
| Saturday, 25 January 2020 |
| Ashton-on-Mersey | 78 | 7 | Hope Valley |
| Burnage 3rd XV | 17 | 39 | Macclesfield 4th XV |
| Glossop 3rd XV | 33 | 10 | Ormskirk 2nd XV |
| Leigh 3rd XV | 3 | 25 | Preston Grasshoppers 4th XV |
| Blackburn 3rd XV | 65 | 19 | Wallasey |
| Hoylake 2nd XV | Home Walkover | Oswestry 2nd XV |
| Eagle | 10 | 10 | Prenton |
| Round 4 |
| Saturday, 22 February 2020 |
| Macclesfield 4th XV | 27 | 21 | Glossop 3rd XV |
| Lostock | 25 | 5 | Ashton-on-Mersey |
| Preston Grasshoppers 4th XV | Home Walkover | Hoylake 2nd XV |
| Saturday, 29 February 2020 |
| Blackburn 3rd XV | 19 | 34 | Prenton |
| Round 5 |
| Saturday, 4 April 2020 |
| Lostock | v | Prenton |
| Preston Grasshoppers 4th XV | v | Macclesfield 4th XV |
| Round 6 |
| Saturday, 2 May 2020 |
| TBC | v | TBC |