| Round 1 |
| Saturday, 28 September 2019 |
| 1 | Tarleton 2nd XV | v | Bye |
| 2 | Southport 2nd XV | v | Bye |
| 3 | Leigh 2nd XV | v | Bye |
| 4 | Leyland Warriors | v | Bye |
| 5 | Littleborough 2nd XV | Home Walkover | Keswick 2nd XV |
| 6 | West Park (St Helens) 2nd XV | 12 | 42 | Aldwinians 2nd XV |
| 8 | Oldham 2nd XV | 17 | 0 | Eccles 2nd XV |
| 9 | Anselmians 2nd XV | 12 | 36 | Altrincham Kersal Cougars (2nd XV) |
| 10 | Helsby | v | Bye |
| 11 | Liverpool Collegiate 2nd XV | 12 | 24 | Holmes Chapel |
| 12 | Manchester 2nd XV | 14 | 57 | Liverpool St Helens 2nd XV |
| 13 | Wilmslow 2nd XV | 36 | 0 | Crewe & Nantwich 2nd XV |
| 14 | Didsbury Toc H 2nd XV | v | Bye |
| 15 | Northwich 2nd XV | 27 | 8 | Moore |
| 16 | Widnes 2nd XV | v | Bye |
| Saturday, 2 November 2019 |
| 7 | De La Salle (Salford) 2nd XV | 13 | 13 | Orrell 2nd XV |
| Round 2 |
| Saturday, 26 October 2019 |
| Leigh 2nd XV | Home Walkover | Leyland Warriors |
| Saturday, 9 November 2019 |
| Tarleton 2nd XV | 36 | 5 | Southport 2nd XV |
| Littleborough 2nd XV | Home Walkover | Aldwinians 2nd XV |
| Orrell 2nd XV | 73 | 0 | Oldham 2nd XV |
| Saturday, 16 November 2019 |
| Wilmslow 2nd XV | 24 | 5 | Didsbury Toc H 2nd XV |
| Saturday, 30 November 2019 |
| Altrincham Kersal Cougars (2nd XV) | 44 | 5 | Helsby |
| Saturday, 14 December 2019 |
| Holmes Chapel | Home Walkover | Liverpool St Helens 2nd XV |
| Saturday, 21 December 2019 |
| Northwich 2nd XV | 18 | 20 | Widnes 2nd XV |
| Round 3 |
| Saturday, 22 February 2020 |
| Tarleton 2nd XV | 34 | 7 | Leigh 2nd XV |
| Littleborough 2nd XV | 25 | 0 | Orrell 2nd XV |
| Altrincham Kersal Cougars (2nd XV) | 29 | 0 | Holmes Chapel |
| Saturday, 28 March 2020 |
| Widnes 2nd XV | v | Wilmslow 2nd XV |
| Round 4 |
| Saturday, 4 April 2020 |
| Littleborough 2nd XV | v | Altrincham Kersal Cougars (2nd XV) |
| TBC | v | Tarleton 2nd XV |
| Round 5 |
| Saturday, 2 May 2020 |
| TBC | v | TBC |