| Saturday, 7 September 2019 |
| Eccles 2nd XV | 50 | 36 | Leyland Warriors |
| Keswick 2nd XV | 24 | 5 | West Park (St Helens) 2nd XV |
| Leigh 2nd XV | 22 | 25 | Tarleton 2nd XV |
| Oldham 2nd XV | 33 | 0 | Littleborough 2nd XV |
| Orrell 2nd XV | 45 | 12 | Aldwinians 2nd XV |
| Saturday, 14 September 2019 |
| Leyland Warriors | 15 | 19 | Keswick 2nd XV |
| Littleborough 2nd XV | 41 | 7 | De La Salle (Salford) 2nd XV |
| Oldham 2nd XV | 22 | 43 | Orrell 2nd XV |
| Southport 2nd XV | 39 | 10 | Aldwinians 2nd XV |
| West Park (St Helens) 2nd XV | 12 | 59 | Leigh 2nd XV |
| Saturday, 21 September 2019 |
| Aldwinians 2nd XV | 29 | 25 | Tarleton 2nd XV |
| De La Salle (Salford) 2nd XV | 73 | 21 | Oldham 2nd XV |
| Eccles 2nd XV | 35 | 29 | Littleborough 2nd XV |
| Leigh 2nd XV | 16 | 24 | Leyland Warriors |
| Orrell 2nd XV | 70 | 0 | Southport 2nd XV |
| Saturday, 28 September 2019 |
| Littleborough 2nd XV | Home Walkover | Keswick 2nd XV |
| Oldham 2nd XV | 17 | 0 | Eccles 2nd XV |
| West Park (St Helens) 2nd XV | 12 | 42 | Aldwinians 2nd XV |
| Saturday, 5 October 2019 |
| Aldwinians 2nd XV | Home Walkover | Leyland Warriors |
| Eccles 2nd XV | 12 | 29 | De La Salle (Salford) 2nd XV |
| Keswick 2nd XV | 36 | 5 | Oldham 2nd XV |
| Leigh 2nd XV | 30 | 13 | Littleborough 2nd XV |
| Orrell 2nd XV | 34 | 0 | Tarleton 2nd XV |
| Southport 2nd XV | 12 | 36 | West Park (St Helens) 2nd XV |
| Saturday, 12 October 2019 |
| Eccles 2nd XV | 12 | 38 | Orrell 2nd XV |
| Leyland Warriors | 21 | 0 | Southport 2nd XV |
| Oldham 2nd XV | 22 | 35 | Leigh 2nd XV |
| Saturday, 19 October 2019 |
| Aldwinians 2nd XV | 17 | 28 | Littleborough 2nd XV |
| Keswick 2nd XV | 52 | 7 | Eccles 2nd XV |
| Leigh 2nd XV | 40 | 19 | De La Salle (Salford) 2nd XV |
| Orrell 2nd XV | 22 | 21 | West Park (St Helens) 2nd XV |
| Tarleton 2nd XV | 22 | 16 | Leyland Warriors |
| Saturday, 2 November 2019 |
| De La Salle (Salford) 2nd XV | 13 | 13 | Orrell 2nd XV |
| West Park (St Helens) 2nd XV | 22 | 10 | Tarleton 2nd XV |
| Saturday, 9 November 2019 |
| Eccles 2nd XV | 6 | 21 | Leigh 2nd XV |
| Leyland Warriors | 21 | 3 | West Park (St Helens) 2nd XV |
| Tarleton 2nd XV | 36 | 5 | Southport 2nd XV |
| Saturday, 16 November 2019 |
| Aldwinians 2nd XV | 73 | 21 | De La Salle (Salford) 2nd XV |
| Leigh 2nd XV | 10 | 21 | Keswick 2nd XV |
| Orrell 2nd XV | 17 | 25 | Leyland Warriors |
| Southport 2nd XV | 55 | 0 | Oldham 2nd XV |
| Tarleton 2nd XV | 38 | 0 | Littleborough 2nd XV |
| Saturday, 23 November 2019 |
| De La Salle (Salford) 2nd XV | 24 | 7 | Southport 2nd XV |
| Eccles 2nd XV | 7 | 17 | Aldwinians 2nd XV |
| Leigh 2nd XV | 39 | 19 | Orrell 2nd XV |
| Littleborough 2nd XV | 25 | 14 | West Park (St Helens) 2nd XV |
| Oldham 2nd XV | 17 | 12 | Tarleton 2nd XV |
| Saturday, 30 November 2019 |
| Aldwinians 2nd XV | 17 | 7 | Keswick 2nd XV |
| Southport 2nd XV | 17 | 58 | Eccles 2nd XV |
| Tarleton 2nd XV | Home Walkover | De La Salle (Salford) 2nd XV |
| West Park (St Helens) 2nd XV | 0 | 0 | Oldham 2nd XV |
| Saturday, 7 December 2019 |
| De La Salle (Salford) 2nd XV | 25 | 16 | West Park (St Helens) 2nd XV |
| Eccles 2nd XV | 26 | 35 | Tarleton 2nd XV |
| Keswick 2nd XV | 31 | 3 | Southport 2nd XV |
| Leigh 2nd XV | 22 | 0 | Aldwinians 2nd XV |
| Oldham 2nd XV | 7 | 24 | Leyland Warriors |
| Saturday, 14 December 2019 |
| Orrell 2nd XV | 12 | 48 | Littleborough 2nd XV |
| Southport 2nd XV | 39 | 0 | Leigh 2nd XV |
| Tarleton 2nd XV | Home Walkover | Keswick 2nd XV |
| West Park (St Helens) 2nd XV | 21 | 10 | Eccles 2nd XV |
| Saturday, 21 December 2019 |
| Littleborough 2nd XV | Home Walkover | Southport 2nd XV |
| Saturday, 4 January 2020 |
| Aldwinians 2nd XV | 64 | 12 | Southport 2nd XV |
| De La Salle (Salford) 2nd XV | 7 | 17 | Littleborough 2nd XV |
| Leigh 2nd XV | 31 | 5 | West Park (St Helens) 2nd XV |
| Orrell 2nd XV | 64 | 0 | Oldham 2nd XV |
| Saturday, 11 January 2020 |
| Leyland Warriors | Home Walkover | Leigh 2nd XV |
| Littleborough 2nd XV | 15 | 19 | Eccles 2nd XV |
| Oldham 2nd XV | 38 | 22 | De La Salle (Salford) 2nd XV |
| Southport 2nd XV | 0 | 54 | Orrell 2nd XV |
| Tarleton 2nd XV | 20 | 12 | Aldwinians 2nd XV |
| Saturday, 18 January 2020 |
| Aldwinians 2nd XV | 0 | 38 | West Park (St Helens) 2nd XV |
| Littleborough 2nd XV | 22 | 21 | Keswick 2nd XV |
| Oldham 2nd XV | 7 | 38 | Eccles 2nd XV |
| Orrell 2nd XV | 44 | 17 | De La Salle (Salford) 2nd XV |
| Southport 2nd XV | 29 | 5 | Tarleton 2nd XV |
| Saturday, 25 January 2020 |
| Aldwinians 2nd XV | 41 | 5 | Oldham 2nd XV |
| De La Salle (Salford) 2nd XV | 26 | 17 | Keswick 2nd XV |
| Leyland Warriors | 38 | 12 | Littleborough 2nd XV |
| Saturday, 1 February 2020 |
| Aldwinians 2nd XV | 38 | 0 | Leyland Warriors |
| Littleborough 2nd XV | 23 | 20 | Leigh 2nd XV |
| Oldham 2nd XV | 12 | 67 | Keswick 2nd XV |
| Tarleton 2nd XV | 18 | 21 | Orrell 2nd XV |
| West Park (St Helens) 2nd XV | 12 | 14 | Southport 2nd XV |
| Saturday, 8 February 2020 |
| Keswick 2nd XV | 14 | 14 | De La Salle (Salford) 2nd XV |
| Leigh 2nd XV | 59 | 12 | Oldham 2nd XV |
| Orrell 2nd XV | 43 | 0 | Eccles 2nd XV |
| Southport 2nd XV | 32 | 17 | Leyland Warriors |
| Tarleton 2nd XV | 16 | 17 | West Park (St Helens) 2nd XV |
| Saturday, 15 February 2020 |
| De La Salle (Salford) 2nd XV | 0 | 5 | Leigh 2nd XV |
| Eccles 2nd XV | 33 | 7 | Keswick 2nd XV |
| Littleborough 2nd XV | Postponed | Aldwinians 2nd XV |
| West Park (St Helens) 2nd XV | 62 | 10 | Orrell 2nd XV |
| Saturday, 29 February 2020 |
| Leigh 2nd XV | 5 | 0 | Eccles 2nd XV |
| Littleborough 2nd XV | 5 | 0 | Southport 2nd XV |
| Orrell 2nd XV | 21 | 19 | Keswick 2nd XV |
| Saturday, 7 March 2020 |
| De La Salle (Salford) 2nd XV | Away Walkover | Aldwinians 2nd XV |
| Keswick 2nd XV | 19 | 15 | Leigh 2nd XV |
| Leyland Warriors | 5 | 5 | Orrell 2nd XV |
| Littleborough 2nd XV | 26 | 22 | Tarleton 2nd XV |
| Oldham 2nd XV | 22 | 14 | Southport 2nd XV |
| Saturday, 14 March 2020 |
| Aldwinians 2nd XV | 78 | 7 | Eccles 2nd XV |
| Keswick 2nd XV | 5 | 0 | Leyland Warriors |
| Orrell 2nd XV | 3 | 33 | Leigh 2nd XV |
| Southport 2nd XV | 5 | 0 | De La Salle (Salford) 2nd XV |
| Tarleton 2nd XV | 12 | 7 | Oldham 2nd XV |
| West Park (St Helens) 2nd XV | 5 | 5 | Littleborough 2nd XV |
| Saturday, 21 March 2020 |
| Eccles 2nd XV | v | Southport 2nd XV |
| Keswick 2nd XV | v | Aldwinians 2nd XV |
| Littleborough 2nd XV | v | Leyland Warriors |
| Tarleton 2nd XV | v | De La Salle (Salford) 2nd XV |
| West Park (St Helens) 2nd XV | 0 | 0 | Oldham 2nd XV |
| Saturday, 28 March 2020 |
| Aldwinians 2nd XV | v | Leigh 2nd XV |
| Leyland Warriors | v | Oldham 2nd XV |
| Southport 2nd XV | v | Keswick 2nd XV |
| Tarleton 2nd XV | v | Eccles 2nd XV |
| West Park (St Helens) 2nd XV | 0 | 0 | De La Salle (Salford) 2nd XV |
| Saturday, 4 April 2020 |
| Aldwinians 2nd XV | v | Oldham 2nd XV |
| De La Salle (Salford) 2nd XV | v | Eccles 2nd XV |
| Keswick 2nd XV | v | Orrell 2nd XV |
| West Park (St Helens) 2nd XV | 0 | 0 | Leyland Warriors |
| Saturday, 11 April 2020 |
| Leyland Warriors | v | Tarleton 2nd XV |
| Saturday, 18 April 2020 |
| De La Salle (Salford) 2nd XV | v | Leyland Warriors |
| De La Salle (Salford) 2nd XV | v | Leyland Warriors |
| Eccles 2nd XV | v | West Park (St Helens) 2nd XV |
| Leigh 2nd XV | v | Southport 2nd XV |
| Littleborough 2nd XV | v | Orrell 2nd XV |
| Tarleton 2nd XV | v | Keswick 2nd XV |
| Saturday, 25 April 2020 |
| Aldwinians 2nd XV | v | Orrell 2nd XV |
| Leyland Warriors | v | Eccles 2nd XV |
| Littleborough 2nd XV | v | Oldham 2nd XV |
| Tarleton 2nd XV | v | Leigh 2nd XV |
| West Park (St Helens) 2nd XV | 0 | 0 | Keswick 2nd XV |