| Saturday, 7 September 2019 |
| Altrincham Kersal Cougars (2nd XV) | 27 | 21 | Manchester 2nd XV |
| Anselmians 2nd XV | 5 | 45 | Wilmslow 2nd XV |
| Liverpool Collegiate 2nd XV | 22 | 7 | Crewe & Nantwich 2nd XV |
| Liverpool St Helens 2nd XV | Home Walkover | Helsby |
| Lymm Eagles | 19 | 64 | Didsbury Toc H 2nd XV |
| Moore | 51 | 28 | Holmes Chapel |
| Northwich 2nd XV | 5 | 58 | Widnes 2nd XV |
| Saturday, 14 September 2019 |
| Anselmians 2nd XV | 25 | 38 | Moore |
| Didsbury Toc H 2nd XV | 29 | 3 | Liverpool St Helens 2nd XV |
| Helsby | 20 | 15 | Holmes Chapel |
| Liverpool Collegiate 2nd XV | 38 | 24 | Lymm Eagles |
| Manchester 2nd XV | 22 | 31 | Crewe & Nantwich 2nd XV |
| Widnes 2nd XV | 17 | 45 | Altrincham Kersal Cougars (2nd XV) |
| Wilmslow 2nd XV | 53 | 0 | Northwich 2nd XV |
| Saturday, 21 September 2019 |
| Altrincham Kersal Cougars (2nd XV) | 17 | 36 | Wilmslow 2nd XV |
| Crewe & Nantwich 2nd XV | 34 | 10 | Widnes 2nd XV |
| Holmes Chapel | 35 | 14 | Didsbury Toc H 2nd XV |
| Liverpool St Helens 2nd XV | 18 | 10 | Liverpool Collegiate 2nd XV |
| Lymm Eagles | 36 | 68 | Manchester 2nd XV |
| Moore | 27 | 25 | Helsby |
| Northwich 2nd XV | 14 | 57 | Anselmians 2nd XV |
| Saturday, 28 September 2019 |
| Anselmians 2nd XV | 12 | 36 | Altrincham Kersal Cougars (2nd XV) |
| Didsbury Toc H 2nd XV | 50 | 0 | Helsby |
| Liverpool Collegiate 2nd XV | 12 | 24 | Holmes Chapel |
| Manchester 2nd XV | 14 | 57 | Liverpool St Helens 2nd XV |
| Northwich 2nd XV | 27 | 8 | Moore |
| Widnes 2nd XV | 57 | 12 | Lymm Eagles |
| Wilmslow 2nd XV | 36 | 0 | Crewe & Nantwich 2nd XV |
| Saturday, 5 October 2019 |
| Altrincham Kersal Cougars (2nd XV) | 55 | 14 | Northwich 2nd XV |
| Crewe & Nantwich 2nd XV | 45 | 5 | Anselmians 2nd XV |
| Helsby | 11 | 14 | Liverpool Collegiate 2nd XV |
| Holmes Chapel | 10 | 20 | Manchester 2nd XV |
| Liverpool St Helens 2nd XV | 39 | 19 | Widnes 2nd XV |
| Lymm Eagles | 5 | 50 | Wilmslow 2nd XV |
| Moore | 31 | 34 | Didsbury Toc H 2nd XV |
| Saturday, 12 October 2019 |
| Altrincham Kersal Cougars (2nd XV) | 39 | 21 | Moore |
| Anselmians 2nd XV | 38 | 19 | Lymm Eagles |
| Liverpool Collegiate 2nd XV | 27 | 45 | Didsbury Toc H 2nd XV |
| Manchester 2nd XV | 45 | 12 | Helsby |
| Northwich 2nd XV | 17 | 28 | Crewe & Nantwich 2nd XV |
| Widnes 2nd XV | 24 | 19 | Holmes Chapel |
| Wilmslow 2nd XV | 11 | 20 | Liverpool St Helens 2nd XV |
| Saturday, 19 October 2019 |
| Crewe & Nantwich 2nd XV | 30 | 28 | Altrincham Kersal Cougars (2nd XV) |
| Didsbury Toc H 2nd XV | 55 | 19 | Manchester 2nd XV |
| Helsby | 0 | 29 | Widnes 2nd XV |
| Holmes Chapel | 16 | 38 | Wilmslow 2nd XV |
| Liverpool St Helens 2nd XV | Home Walkover | Anselmians 2nd XV |
| Lymm Eagles | 31 | 24 | Northwich 2nd XV |
| Moore | 16 | 27 | Liverpool Collegiate 2nd XV |
| Saturday, 9 November 2019 |
| Altrincham Kersal Cougars (2nd XV) | 45 | 17 | Lymm Eagles |
| Anselmians 2nd XV | 5 | 0 | Holmes Chapel |
| Manchester 2nd XV | 44 | 15 | Liverpool Collegiate 2nd XV |
| Widnes 2nd XV | 15 | 18 | Didsbury Toc H 2nd XV |
| Wilmslow 2nd XV | 67 | 0 | Helsby |
| Saturday, 16 November 2019 |
| Helsby | 12 | 43 | Anselmians 2nd XV |
| Holmes Chapel | 26 | 14 | Northwich 2nd XV |
| Liverpool Collegiate 2nd XV | 8 | 27 | Widnes 2nd XV |
| Liverpool St Helens 2nd XV | 42 | 7 | Altrincham Kersal Cougars (2nd XV) |
| Lymm Eagles | 27 | 23 | Crewe & Nantwich 2nd XV |
| Moore | 45 | 7 | Manchester 2nd XV |
| Wilmslow 2nd XV | 24 | 5 | Didsbury Toc H 2nd XV |
| Saturday, 23 November 2019 |
| Altrincham Kersal Cougars (2nd XV) | 14 | 37 | Holmes Chapel |
| Anselmians 2nd XV | 15 | 19 | Didsbury Toc H 2nd XV |
| Crewe & Nantwich 2nd XV | 0 | 7 | Liverpool St Helens 2nd XV |
| Lymm Eagles | 26 | 29 | Moore |
| Northwich 2nd XV | 17 | 10 | Helsby |
| Widnes 2nd XV | 27 | 12 | Manchester 2nd XV |
| Wilmslow 2nd XV | 34 | 29 | Liverpool Collegiate 2nd XV |
| Saturday, 30 November 2019 |
| Didsbury Toc H 2nd XV | 14 | 31 | Northwich 2nd XV |
| Holmes Chapel | Home Walkover | Crewe & Nantwich 2nd XV |
| Liverpool Collegiate 2nd XV | 40 | 28 | Anselmians 2nd XV |
| Liverpool St Helens 2nd XV | 33 | 19 | Lymm Eagles |
| Manchester 2nd XV | 17 | 41 | Wilmslow 2nd XV |
| Saturday, 7 December 2019 |
| Altrincham Kersal Cougars (2nd XV) | 15 | 50 | Didsbury Toc H 2nd XV |
| Anselmians 2nd XV | Home Walkover | Manchester 2nd XV |
| Crewe & Nantwich 2nd XV | 55 | 10 | Helsby |
| Liverpool St Helens 2nd XV | 25 | 12 | Moore |
| Lymm Eagles | 28 | 57 | Holmes Chapel |
| Northwich 2nd XV | 28 | 17 | Liverpool Collegiate 2nd XV |
| Wilmslow 2nd XV | 29 | 19 | Widnes 2nd XV |
| Saturday, 14 December 2019 |
| Helsby | 30 | 46 | Lymm Eagles |
| Holmes Chapel | Home Walkover | Liverpool St Helens 2nd XV |
| Liverpool Collegiate 2nd XV | 17 | 59 | Altrincham Kersal Cougars (2nd XV) |
| Manchester 2nd XV | 19 | 23 | Northwich 2nd XV |
| Moore | 10 | 5 | Wilmslow 2nd XV |
| Saturday, 4 January 2020 |
| Altrincham Kersal Cougars (2nd XV) | 33 | 12 | Widnes 2nd XV |
| Crewe & Nantwich 2nd XV | 14 | 52 | Manchester 2nd XV |
| Holmes Chapel | 45 | 0 | Helsby |
| Liverpool St Helens 2nd XV | 29 | 22 | Didsbury Toc H 2nd XV |
| Lymm Eagles | 65 | 5 | Liverpool Collegiate 2nd XV |
| Moore | 85 | 12 | Anselmians 2nd XV |
| Northwich 2nd XV | 12 | 41 | Wilmslow 2nd XV |
| Saturday, 11 January 2020 |
| Anselmians 2nd XV | 33 | 0 | Northwich 2nd XV |
| Didsbury Toc H 2nd XV | 10 | 22 | Holmes Chapel |
| Helsby | 0 | 22 | Moore |
| Liverpool Collegiate 2nd XV | 32 | 7 | Liverpool St Helens 2nd XV |
| Manchester 2nd XV | 87 | 0 | Lymm Eagles |
| Widnes 2nd XV | 24 | 31 | Crewe & Nantwich 2nd XV |
| Wilmslow 2nd XV | 44 | 19 | Altrincham Kersal Cougars (2nd XV) |
| Saturday, 18 January 2020 |
| Altrincham Kersal Cougars (2nd XV) | 29 | 7 | Anselmians 2nd XV |
| Crewe & Nantwich 2nd XV | 7 | 29 | Wilmslow 2nd XV |
| Helsby | 10 | 31 | Didsbury Toc H 2nd XV |
| Holmes Chapel | 29 | 0 | Liverpool Collegiate 2nd XV |
| Liverpool St Helens 2nd XV | 7 | 38 | Manchester 2nd XV |
| Moore | 33 | 24 | Northwich 2nd XV |
| Saturday, 25 January 2020 |
| Crewe & Nantwich 2nd XV | 0 | 21 | Moore |
| Northwich 2nd XV | 17 | 22 | Liverpool St Helens 2nd XV |
| Widnes 2nd XV | 21 | 0 | Anselmians 2nd XV |
| Saturday, 1 February 2020 |
| Anselmians 2nd XV | 12 | 45 | Crewe & Nantwich 2nd XV |
| Didsbury Toc H 2nd XV | 7 | 17 | Moore |
| Liverpool Collegiate 2nd XV | 44 | 17 | Helsby |
| Manchester 2nd XV | 17 | 21 | Holmes Chapel |
| Northwich 2nd XV | 10 | 20 | Altrincham Kersal Cougars (2nd XV) |
| Widnes 2nd XV | 30 | 5 | Liverpool St Helens 2nd XV |
| Wilmslow 2nd XV | Home Walkover | Lymm Eagles |
| Saturday, 8 February 2020 |
| Crewe & Nantwich 2nd XV | 65 | 7 | Northwich 2nd XV |
| Helsby | 27 | 17 | Manchester 2nd XV |
| Holmes Chapel | 52 | 17 | Widnes 2nd XV |
| Liverpool St Helens 2nd XV | 0 | 33 | Wilmslow 2nd XV |
| Lymm Eagles | 19 | 24 | Anselmians 2nd XV |
| Moore | 12 | 7 | Altrincham Kersal Cougars (2nd XV) |
| Saturday, 15 February 2020 |
| Altrincham Kersal Cougars (2nd XV) | 28 | 0 | Crewe & Nantwich 2nd XV |
| Liverpool Collegiate 2nd XV | 24 | 0 | Moore |
| Wilmslow 2nd XV | Postponed | Holmes Chapel |
| Saturday, 22 February 2020 |
| Didsbury Toc H 2nd XV | Home Walkover | Crewe & Nantwich 2nd XV |
| Northwich 2nd XV | 49 | 27 | Lymm Eagles |
| Saturday, 29 February 2020 |
| Didsbury Toc H 2nd XV | 22 | 7 | Widnes 2nd XV |
| Helsby | 0 | 8 | Wilmslow 2nd XV |
| Holmes Chapel | 8 | 0 | Anselmians 2nd XV |
| Liverpool Collegiate 2nd XV | 0 | 84 | Manchester 2nd XV |
| Liverpool St Helens 2nd XV | 5 | 0 | Northwich 2nd XV |
| Lymm Eagles | 7 | 67 | Altrincham Kersal Cougars (2nd XV) |
| Saturday, 7 March 2020 |
| Altrincham Kersal Cougars (2nd XV) | 45 | 5 | Liverpool St Helens 2nd XV |
| Anselmians 2nd XV | 37 | 7 | Helsby |
| Crewe & Nantwich 2nd XV | Home Walkover | Lymm Eagles |
| Didsbury Toc H 2nd XV | 5 | 40 | Wilmslow 2nd XV |
| Manchester 2nd XV | 3 | 22 | Moore |
| Northwich 2nd XV | 12 | 55 | Holmes Chapel |
| Widnes 2nd XV | Home Walkover | Liverpool Collegiate 2nd XV |
| Friday, 13 March 2020 |
| Moore | 20 | 21 | Lymm Eagles |
| Saturday, 14 March 2020 |
| Didsbury Toc H 2nd XV | 5 | 0 | Anselmians 2nd XV |
| Helsby | 22 | 31 | Northwich 2nd XV |
| Holmes Chapel | 57 | 12 | Altrincham Kersal Cougars (2nd XV) |
| Liverpool Collegiate 2nd XV | 0 | 59 | Wilmslow 2nd XV |
| Liverpool St Helens 2nd XV | 5 | 34 | Crewe & Nantwich 2nd XV |
| Manchester 2nd XV | 12 | 14 | Widnes 2nd XV |
| Saturday, 21 March 2020 |
| Altrincham Kersal Cougars (2nd XV) | v | Helsby |
| Anselmians 2nd XV | v | Liverpool Collegiate 2nd XV |
| Helsby | v | Altrincham Kersal Cougars (2nd XV) |
| Holmes Chapel | v | Crewe & Nantwich 2nd XV |
| Lymm Eagles | v | Liverpool St Helens 2nd XV |
| Northwich 2nd XV | v | Didsbury Toc H 2nd XV |
| Widnes 2nd XV | v | Moore |
| Widnes 2nd XV | v | Moore |
| Wilmslow 2nd XV | v | Manchester 2nd XV |
| Saturday, 28 March 2020 |
| Anselmians 2nd XV | v | Manchester 2nd XV |
| Didsbury Toc H 2nd XV | v | Altrincham Kersal Cougars (2nd XV) |
| Helsby | v | Crewe & Nantwich 2nd XV |
| Holmes Chapel | v | Lymm Eagles |
| Liverpool Collegiate 2nd XV | v | Northwich 2nd XV |
| Moore | v | Liverpool St Helens 2nd XV |
| Widnes 2nd XV | v | Wilmslow 2nd XV |
| Saturday, 4 April 2020 |
| Didsbury Toc H 2nd XV | v | Liverpool Collegiate 2nd XV |
| Liverpool St Helens 2nd XV | v | Anselmians 2nd XV |
| Lymm Eagles | v | Widnes 2nd XV |
| Moore | v | Crewe & Nantwich 2nd XV |
| Saturday, 11 April 2020 |
| Manchester 2nd XV | v | Didsbury Toc H 2nd XV |
| Widnes 2nd XV | v | Helsby |
| Saturday, 18 April 2020 |
| Altrincham Kersal Cougars (2nd XV) | v | Liverpool Collegiate 2nd XV |
| Anselmians 2nd XV | v | Widnes 2nd XV |
| Didsbury Toc H 2nd XV | v | Crewe & Nantwich 2nd XV |
| Holmes Chapel | v | Liverpool St Helens 2nd XV |
| Lymm Eagles | v | Helsby |
| Northwich 2nd XV | v | Manchester 2nd XV |
| Wilmslow 2nd XV | v | Moore |
| Saturday, 25 April 2020 |
| Crewe & Nantwich 2nd XV | v | Liverpool Collegiate 2nd XV |
| Didsbury Toc H 2nd XV | v | Lymm Eagles |
| Holmes Chapel | v | Moore |
| Liverpool St Helens 2nd XV | v | Helsby |
| Manchester 2nd XV | v | Altrincham Kersal Cougars (2nd XV) |
| Widnes 2nd XV | v | Northwich 2nd XV |
| Wilmslow 2nd XV | v | Anselmians 2nd XV |