| Saturday, 4 September 2021 |
| Blackburn 3rd XV | 44 | 6 | Rossendale 3rd XV |
| Blackpool | 33 | 7 | Ormskirk 2nd XV |
| Fleetwood 2nd XV | 7 | 46 | Fylde Vandals (4th XV) |
| Leigh 3rd XV | 23 | 56 | Lostock |
| Saturday, 11 September 2021 |
| Fylde Vandals (4th XV) | 19 | 33 | Blackburn 3rd XV |
| Lostock | 62 | 5 | Fleetwood 2nd XV |
| Rossendale 3rd XV | 17 | 26 | Preston Grasshoppers 4th XV |
| Saturday, 18 September 2021 |
| Blackburn 3rd XV | 13 | 30 | Lostock |
| Preston Grasshoppers 4th XV | 27 | 15 | Fylde Vandals (4th XV) |
| Rochdale 3rd XV | 17 | 31 | Blackpool |
| Saturday, 25 September 2021 |
| Blackpool | 83 | 7 | Leigh 3rd XV |
| Lostock | 41 | 3 | Preston Grasshoppers 4th XV |
| Ormskirk 2nd XV | 60 | 12 | Rossendale 3rd XV |
| Saturday, 2 October 2021 |
| Fleetwood 2nd XV | 25 | 22 | Blackpool |
| Rochdale 3rd XV | 7 | 41 | Ormskirk 2nd XV |
| Rossendale 3rd XV | 23 | 41 | Fylde Vandals (4th XV) |
| Saturday, 16 October 2021 |
| Blackpool | Home Walkover | Blackburn 3rd XV |
| Lostock | Home Walkover | Rossendale 3rd XV |
| Ormskirk 2nd XV | 38 | 21 | Fylde Vandals (4th XV) |
| Saturday, 23 October 2021 |
| Fleetwood 2nd XV | 5 | 48 | Rochdale 3rd XV |
| Fylde Vandals (4th XV) | Away Walkover | Lostock |
| Leigh 3rd XV | 16 | 19 | Ormskirk 2nd XV |
| Preston Grasshoppers 4th XV | 19 | 36 | Blackpool |
| Saturday, 30 October 2021 |
| Leigh 3rd XV | 41 | 7 | Fleetwood 2nd XV |
| Ormskirk 2nd XV | 25 | 27 | Lostock |
| Rochdale 3rd XV | 14 | 23 | Blackburn 3rd XV |
| Saturday, 13 November 2021 |
| Blackburn 3rd XV | 40 | 12 | Leigh 3rd XV |
| Fleetwood 2nd XV | 34 | 34 | Ormskirk 2nd XV |
| Preston Grasshoppers 4th XV | Home Walkover | Rochdale 3rd XV |
| Rossendale 3rd XV | Away Walkover | Blackpool |
| Saturday, 20 November 2021 |
| Blackpool | 13 | 6 | Fylde Vandals (4th XV) |
| Fleetwood 2nd XV | 0 | 25 | Blackburn 3rd XV |
| Leigh 3rd XV | 15 | 24 | Preston Grasshoppers 4th XV |
| Ormskirk 2nd XV | 43 | 34 | Rochdale 3rd XV |
| Saturday, 27 November 2021 |
| Blackburn 3rd XV | 29 | 33 | Ormskirk 2nd XV |
| Lostock | 44 | 17 | Blackpool |
| Preston Grasshoppers 4th XV | 54 | 40 | Fleetwood 2nd XV |
| Saturday, 4 December 2021 |
| Blackburn 3rd XV | Away Walkover | Preston Grasshoppers 4th XV |
| Leigh 3rd XV | 5 | 15 | Rossendale 3rd XV |
| Saturday, 11 December 2021 |
| Fylde Vandals (4th XV) | 22 | 12 | Leigh 3rd XV |
| Lostock | Home Walkover | Rochdale 3rd XV |
| Ormskirk 2nd XV | 17 | 14 | Preston Grasshoppers 4th XV |
| Rossendale 3rd XV | Home Walkover | Fleetwood 2nd XV |
| Saturday, 8 January 2022 |
| Blackpool | 39 | 5 | Rochdale 3rd XV |
| Fylde Vandals (4th XV) | 13 | 19 | Preston Grasshoppers 4th XV |
| Saturday, 15 January 2022 |
| Leigh 3rd XV | 27 | 14 | Blackpool |
| Preston Grasshoppers 4th XV | 13 | 46 | Lostock |
| Rochdale 3rd XV | 34 | 24 | Fylde Vandals (4th XV) |
| Rossendale 3rd XV | 22 | 70 | Ormskirk 2nd XV |
| Saturday, 22 January 2022 |
| Blackpool | 32 | 7 | Fleetwood 2nd XV |
| Fylde Vandals (4th XV) | 82 | 34 | Rossendale 3rd XV |
| Saturday, 29 January 2022 |
| Blackpool | 25 | 20 | Blackburn 3rd XV |
| Fylde Vandals (4th XV) | 40 | 62 | Ormskirk 2nd XV |
| Leigh 3rd XV | 25 | 17 | Rochdale 3rd XV |
| Lostock | Home Walkover | Rossendale 3rd XV |
| Saturday, 12 February 2022 |
| Blackpool | 24 | 15 | Preston Grasshoppers 4th XV |
| Lostock | Home Walkover | Fylde Vandals (4th XV) |
| Ormskirk 2nd XV | 29 | 26 | Leigh 3rd XV |
| Rochdale 3rd XV | 13 | 66 | Fleetwood 2nd XV |
| Saturday, 19 February 2022 |
| Fleetwood 2nd XV | 5 | 5 | Leigh 3rd XV |
| Lostock | 5 | 5 | Ormskirk 2nd XV |
| Saturday, 26 February 2022 |
| Blackburn 3rd XV | 50 | 17 | Rochdale 3rd XV |
| Saturday, 5 March 2022 |
| Blackpool | 76 | 22 | Rossendale 3rd XV |
| Leigh 3rd XV | 23 | 27 | Blackburn 3rd XV |
| Ormskirk 2nd XV | 62 | 37 | Fleetwood 2nd XV |
| Preston Grasshoppers 4th XV | 77 | 14 | Rochdale 3rd XV |
| Saturday, 12 March 2022 |
| Blackburn 3rd XV | Home Walkover | Fleetwood 2nd XV |
| Fylde Vandals (4th XV) | 54 | 28 | Blackpool |
| Preston Grasshoppers 4th XV | Home Walkover | Leigh 3rd XV |
| Rossendale 3rd XV | 27 | 40 | Rochdale 3rd XV |
| Saturday, 19 March 2022 |
| Lostock | 9 | 0 | Blackburn 3rd XV |
| Rochdale 3rd XV | 12 | 21 | Leigh 3rd XV |
| Saturday, 26 March 2022 |
| Blackpool | 20 | 15 | Lostock |
| Fleetwood 2nd XV | 50 | 26 | Preston Grasshoppers 4th XV |
| Ormskirk 2nd XV | 26 | 39 | Blackburn 3rd XV |
| Rochdale 3rd XV | 21 | 17 | Rossendale 3rd XV |
| Saturday, 2 April 2022 |
| Fylde Vandals (4th XV) | Home Walkover | Rochdale 3rd XV |
| Preston Grasshoppers 4th XV | 10 | 57 | Blackburn 3rd XV |
| Rossendale 3rd XV | Home Walkover | Leigh 3rd XV |
| Saturday, 9 April 2022 |
| Leigh 3rd XV | 17 | 12 | Fylde Vandals (4th XV) |
| Lostock | 55 | 7 | Rochdale 3rd XV |
| Preston Grasshoppers 4th XV | 12 | 41 | Ormskirk 2nd XV |
| Rossendale 3rd XV | 80 | 10 | Fleetwood 2nd XV |
| Saturday, 23 April 2022 |
| Fylde Vandals (4th XV) | 14 | 58 | Fleetwood 2nd XV |
| Lostock | 47 | 7 | Leigh 3rd XV |
| Ormskirk 2nd XV | 29 | 12 | Blackpool |
| Rossendale 3rd XV | 0 | 63 | Blackburn 3rd XV |
| Saturday, 30 April 2022 |
| Blackburn 3rd XV | 57 | 21 | Fylde Vandals (4th XV) |
| Fleetwood 2nd XV | Home Walkover | Lostock |
| Preston Grasshoppers 4th XV | Away Walkover | Rossendale 3rd XV |