| Saturday, 4 September 2021 |
| Leek 2nds | 54 | 34 | Whitchurch 2nd XV |
| Lymm Eagles | Away Walkover | Linley & Kidsgrove 1st XV |
| Northwich 2nd XV | 13 | 47 | Sandbach 3rd XV |
| Oswestry 2nd XV | 42 | 12 | Winnington Park 2nd XV |
| Saturday, 11 September 2021 |
| Newcastle (Staffs) 2nd XV | 17 | 36 | Linley & Kidsgrove 1st XV |
| Whitchurch 2nd XV | Home Walkover | Northwich 2nd XV |
| Winnington Park 2nd XV | 34 | 26 | Lymm Eagles |
| Wirral 3rd XV | 24 | 53 | Oswestry 2nd XV |
| Saturday, 18 September 2021 |
| Heaton Moor 2nd XV | 35 | 0 | Newcastle (Staffs) 2nd XV |
| Linley & Kidsgrove 1st XV | 34 | 21 | Winnington Park 2nd XV |
| Lymm Eagles | 87 | 5 | Wirral 3rd XV |
| Oswestry 2nd XV | 17 | 23 | Sandbach 3rd XV |
| Saturday, 25 September 2021 |
| Heaton Moor 2nd XV | 28 | 10 | Leek 2nds |
| Lymm Eagles | 0 | 60 | Sandbach 3rd XV |
| Newcastle (Staffs) 2nd XV | 40 | 19 | Winnington Park 2nd XV |
| Whitchurch 2nd XV | 93 | 0 | Oswestry 2nd XV |
| Saturday, 2 October 2021 |
| Leek 2nds | 43 | 19 | Newcastle (Staffs) 2nd XV |
| Lymm Eagles | 17 | 14 | Whitchurch 2nd XV |
| Northwich 2nd XV | 22 | 19 | Heaton Moor 2nd XV |
| Sandbach 3rd XV | 35 | 10 | Linley & Kidsgrove 1st XV |
| Winnington Park 2nd XV | 15 | 19 | Wirral 3rd XV |
| Saturday, 16 October 2021 |
| Leek 2nds | 52 | 14 | Northwich 2nd XV |
| Newcastle (Staffs) 2nd XV | 7 | 37 | Wirral 3rd XV |
| Sandbach 3rd XV | 52 | 12 | Winnington Park 2nd XV |
| Whitchurch 2nd XV | 70 | 0 | Linley & Kidsgrove 1st XV |
| Saturday, 23 October 2021 |
| Northwich 2nd XV | 48 | 0 | Newcastle (Staffs) 2nd XV |
| Oswestry 2nd XV | 15 | 29 | Heaton Moor 2nd XV |
| Winnington Park 2nd XV | 17 | 24 | Whitchurch 2nd XV |
| Wirral 3rd XV | 14 | 24 | Sandbach 3rd XV |
| Saturday, 30 October 2021 |
| Leek 2nds | 122 | 5 | Oswestry 2nd XV |
| Whitchurch 2nd XV | 41 | 12 | Wirral 3rd XV |
| Saturday, 6 November 2021 |
| Lymm Eagles | 48 | 12 | Heaton Moor 2nd XV |
| Saturday, 13 November 2021 |
| Heaton Moor 2nd XV | 87 | 7 | Linley & Kidsgrove 1st XV |
| Lymm Eagles | 17 | 51 | Leek 2nds |
| Oswestry 2nd XV | 12 | 17 | Northwich 2nd XV |
| Sandbach 3rd XV | 17 | 33 | Whitchurch 2nd XV |
| Saturday, 20 November 2021 |
| Leek 2nds | 50 | 24 | Linley & Kidsgrove 1st XV |
| Newcastle (Staffs) 2nd XV | 0 | 101 | Whitchurch 2nd XV |
| Northwich 2nd XV | 17 | 52 | Lymm Eagles |
| Winnington Park 2nd XV | 26 | 46 | Heaton Moor 2nd XV |
| Saturday, 27 November 2021 |
| Linley & Kidsgrove 1st XV | 42 | 0 | Northwich 2nd XV |
| Oswestry 2nd XV | 17 | 31 | Newcastle (Staffs) 2nd XV |
| Winnington Park 2nd XV | 12 | 53 | Leek 2nds |
| Wirral 3rd XV | 30 | 29 | Heaton Moor 2nd XV |
| Saturday, 4 December 2021 |
| Heaton Moor 2nd XV | 0 | 70 | Sandbach 3rd XV |
| Leek 2nds | Home Walkover | Wirral 3rd XV |
| Northwich 2nd XV | Away Walkover | Winnington Park 2nd XV |
| Saturday, 11 December 2021 |
| Leek 2nds | 7 | 38 | Sandbach 3rd XV |
| Linley & Kidsgrove 1st XV | 36 | 3 | Oswestry 2nd XV |
| Lymm Eagles | 57 | 0 | Newcastle (Staffs) 2nd XV |
| Whitchurch 2nd XV | Home Walkover | Heaton Moor 2nd XV |
| Saturday, 8 January 2022 |
| Newcastle (Staffs) 2nd XV | 22 | 19 | Heaton Moor 2nd XV |
| Sandbach 3rd XV | 76 | 0 | Oswestry 2nd XV |
| Winnington Park 2nd XV | 21 | 12 | Linley & Kidsgrove 1st XV |
| Wirral 3rd XV | 33 | 26 | Lymm Eagles |
| Saturday, 15 January 2022 |
| Leek 2nds | Home Walkover | Heaton Moor 2nd XV |
| Linley & Kidsgrove 1st XV | Home Walkover | Wirral 3rd XV |
| Oswestry 2nd XV | 7 | 29 | Whitchurch 2nd XV |
| Sandbach 3rd XV | 20 | 21 | Lymm Eagles |
| Winnington Park 2nd XV | 89 | 0 | Newcastle (Staffs) 2nd XV |
| Saturday, 22 January 2022 |
| Heaton Moor 2nd XV | 36 | 12 | Northwich 2nd XV |
| Newcastle (Staffs) 2nd XV | 14 | 59 | Leek 2nds |
| Whitchurch 2nd XV | 64 | 7 | Lymm Eagles |
| Wirral 3rd XV | Home Walkover | Winnington Park 2nd XV |
| Saturday, 29 January 2022 |
| Linley & Kidsgrove 1st XV | 0 | 40 | Whitchurch 2nd XV |
| Northwich 2nd XV | 12 | 35 | Leek 2nds |
| Oswestry 2nd XV | 19 | 37 | Lymm Eagles |
| Winnington Park 2nd XV | 17 | 36 | Sandbach 3rd XV |
| Wirral 3rd XV | 29 | 5 | Newcastle (Staffs) 2nd XV |
| Saturday, 5 February 2022 |
| Wirral 3rd XV | 17 | 24 | Northwich 2nd XV |
| Saturday, 12 February 2022 |
| Heaton Moor 2nd XV | 13 | 12 | Oswestry 2nd XV |
| Linley & Kidsgrove 1st XV | 0 | 29 | Sandbach 3rd XV |
| Newcastle (Staffs) 2nd XV | 14 | 10 | Northwich 2nd XV |
| Whitchurch 2nd XV | 56 | 0 | Winnington Park 2nd XV |
| Saturday, 19 February 2022 |
| Sandbach 3rd XV | 56 | 5 | Newcastle (Staffs) 2nd XV |
| Wirral 3rd XV | 0 | 5 | Whitchurch 2nd XV |
| Saturday, 26 February 2022 |
| Heaton Moor 2nd XV | 29 | 14 | Lymm Eagles |
| Leek 2nds | 60 | 12 | Wirral 3rd XV |
| Saturday, 5 March 2022 |
| Leek 2nds | Home Walkover | Lymm Eagles |
| Linley & Kidsgrove 1st XV | Away Walkover | Heaton Moor 2nd XV |
| Northwich 2nd XV | 24 | 19 | Oswestry 2nd XV |
| Whitchurch 2nd XV | 32 | 19 | Sandbach 3rd XV |
| Saturday, 12 March 2022 |
| Heaton Moor 2nd XV | 17 | 50 | Winnington Park 2nd XV |
| Linley & Kidsgrove 1st XV | 0 | 64 | Leek 2nds |
| Lymm Eagles | 59 | 14 | Northwich 2nd XV |
| Sandbach 3rd XV | 56 | 12 | Wirral 3rd XV |
| Whitchurch 2nd XV | 56 | 0 | Newcastle (Staffs) 2nd XV |
| Saturday, 19 March 2022 |
| Linley & Kidsgrove 1st XV | Away Walkover | Wirral 3rd XV |
| Newcastle (Staffs) 2nd XV | 0 | 5 | Sandbach 3rd XV |
| Oswestry 2nd XV | 17 | 35 | Leek 2nds |
| Saturday, 26 March 2022 |
| Heaton Moor 2nd XV | 59 | 29 | Wirral 3rd XV |
| Leek 2nds | 62 | 17 | Winnington Park 2nd XV |
| Newcastle (Staffs) 2nd XV | 62 | 12 | Oswestry 2nd XV |
| Northwich 2nd XV | 71 | 17 | Linley & Kidsgrove 1st XV |
| Saturday, 2 April 2022 |
| Lymm Eagles | 86 | 10 | Oswestry 2nd XV |
| Sandbach 3rd XV | Home Walkover | Heaton Moor 2nd XV |
| Winnington Park 2nd XV | 34 | 12 | Northwich 2nd XV |
| Saturday, 9 April 2022 |
| Newcastle (Staffs) 2nd XV | Home Walkover | Lymm Eagles |
| Northwich 2nd XV | 38 | 29 | Wirral 3rd XV |
| Oswestry 2nd XV | 23 | 17 | Linley & Kidsgrove 1st XV |
| Sandbach 3rd XV | 17 | 38 | Leek 2nds |
| Whitchurch 2nd XV | 83 | 6 | Heaton Moor 2nd XV |
| Saturday, 23 April 2022 |
| Linley & Kidsgrove 1st XV | 8 | 33 | Lymm Eagles |
| Sandbach 3rd XV | 66 | 5 | Northwich 2nd XV |
| Whitchurch 2nd XV | 17 | 40 | Leek 2nds |
| Winnington Park 2nd XV | 60 | 10 | Oswestry 2nd XV |
| Saturday, 30 April 2022 |
| Linley & Kidsgrove 1st XV | 45 | 7 | Newcastle (Staffs) 2nd XV |
| Lymm Eagles | 42 | 42 | Winnington Park 2nd XV |
| Oswestry 2nd XV | 17 | 26 | Wirral 3rd XV |
| Whitchurch 2nd XV | 62 | 7 | Northwich 2nd XV |