| Saturday, 4 September 2021 |
| Colne & Nelson 2nd XV | 22 | 12 | Garstang Blues (2nd XV) |
| Preston Grasshoppers 6th XV | 49 | 26 | Preston Grasshoppers 5th XV |
| Saturday, 11 September 2021 |
| Garstang Blues (2nd XV) | 50 | 26 | Aspull 3rd XV |
| Preston Grasshoppers 5th XV | 29 | 31 | Bolton 3rd XV |
| Preston Grasshoppers 6th XV | 0 | 47 | Vale of Lune 3rd XV |
| Saturday, 18 September 2021 |
| Bolton 3rd XV | 22 | 21 | Vale of Lune 3rd XV |
| Saturday, 25 September 2021 |
| Preston Grasshoppers 5th XV | 29 | 59 | Clitheroe 2nd XV |
| Preston Grasshoppers 6th XV | Away Walkover | Bolton 3rd XV |
| Saturday, 2 October 2021 |
| Clitheroe 2nd XV | 10 | 44 | Vale of Lune 3rd XV |
| Colne & Nelson 2nd XV | 8 | 33 | Preston Grasshoppers 5th XV |
| Saturday, 16 October 2021 |
| Preston Grasshoppers 5th XV | 21 | 66 | Aspull 3rd XV |
| Preston Grasshoppers 6th XV | 5 | 22 | Clitheroe 2nd XV |
| Vale of Lune 3rd XV | 40 | 17 | Colne & Nelson 2nd XV |
| Saturday, 23 October 2021 |
| Aspull 3rd XV | 7 | 30 | Vale of Lune 3rd XV |
| Clitheroe 2nd XV | 51 | 12 | Bolton 3rd XV |
| Saturday, 30 October 2021 |
| Bolton 3rd XV | 5 | 19 | Colne & Nelson 2nd XV |
| Preston Grasshoppers 5th XV | 13 | 10 | Garstang Blues (2nd XV) |
| Preston Grasshoppers 6th XV | 12 | 34 | Aspull 3rd XV |
| Saturday, 13 November 2021 |
| Aspull 3rd XV | Home Walkover | Bolton 3rd XV |
| Garstang Blues (2nd XV) | 30 | 17 | Vale of Lune 3rd XV |
| Saturday, 20 November 2021 |
| Clitheroe 2nd XV | 10 | 5 | Colne & Nelson 2nd XV |
| Preston Grasshoppers 6th XV | 10 | 33 | Garstang Blues (2nd XV) |
| Saturday, 27 November 2021 |
| Garstang Blues (2nd XV) | 50 | 0 | Bolton 3rd XV |
| Saturday, 4 December 2021 |
| Aspull 3rd XV | 26 | 17 | Colne & Nelson 2nd XV |
| Saturday, 11 December 2021 |
| Garstang Blues (2nd XV) | 7 | 0 | Clitheroe 2nd XV |
| Saturday, 8 January 2022 |
| Vale of Lune 3rd XV | Home Walkover | Bolton 3rd XV |
| Saturday, 15 January 2022 |
| Clitheroe 2nd XV | 29 | 48 | Preston Grasshoppers 5th XV |
| Colne & Nelson 2nd XV | 73 | 0 | Preston Grasshoppers 6th XV |
| Saturday, 22 January 2022 |
| Bolton 3rd XV | 12 | 31 | Preston Grasshoppers 6th XV |
| Preston Grasshoppers 5th XV | 22 | 5 | Colne & Nelson 2nd XV |
| Vale of Lune 3rd XV | 10 | 13 | Clitheroe 2nd XV |
| Saturday, 29 January 2022 |
| Aspull 3rd XV | 31 | 29 | Preston Grasshoppers 5th XV |
| Clitheroe 2nd XV | 24 | 34 | Preston Grasshoppers 6th XV |
| Colne & Nelson 2nd XV | 0 | 41 | Vale of Lune 3rd XV |
| Saturday, 5 February 2022 |
| Aspull 3rd XV | 39 | 20 | Clitheroe 2nd XV |
| Saturday, 12 February 2022 |
| Bolton 3rd XV | 5 | 22 | Clitheroe 2nd XV |
| Saturday, 19 February 2022 |
| Aspull 3rd XV | Away Walkover | Preston Grasshoppers 6th XV |
| Saturday, 26 February 2022 |
| Preston Grasshoppers 6th XV | Home Walkover | Colne & Nelson 2nd XV |
| Saturday, 5 March 2022 |
| Vale of Lune 3rd XV | 30 | 5 | Garstang Blues (2nd XV) |
| Saturday, 12 March 2022 |
| Colne & Nelson 2nd XV | 18 | 10 | Bolton 3rd XV |
| Garstang Blues (2nd XV) | 22 | 12 | Preston Grasshoppers 6th XV |
| Vale of Lune 3rd XV | 65 | 0 | Aspull 3rd XV |
| Saturday, 19 March 2022 |
| Aspull 3rd XV | 33 | 17 | Bolton 3rd XV |
| Colne & Nelson 2nd XV | 57 | 7 | Clitheroe 2nd XV |
| Garstang Blues (2nd XV) | 0 | 26 | Preston Grasshoppers 5th XV |
| Vale of Lune 3rd XV | 96 | 0 | Preston Grasshoppers 6th XV |
| Saturday, 26 March 2022 |
| Bolton 3rd XV | 30 | 33 | Garstang Blues (2nd XV) |
| Clitheroe 2nd XV | 7 | 33 | Aspull 3rd XV |
| Preston Grasshoppers 5th XV | Away Walkover | Vale of Lune 3rd XV |
| Saturday, 2 April 2022 |
| Colne & Nelson 2nd XV | Home Walkover | Aspull 3rd XV |
| Saturday, 9 April 2022 |
| Clitheroe 2nd XV | 26 | 21 | Garstang Blues (2nd XV) |
| Vale of Lune 3rd XV | Home Walkover | Preston Grasshoppers 5th XV |
| Saturday, 23 April 2022 |
| Garstang Blues (2nd XV) | 55 | 24 | Colne & Nelson 2nd XV |
| Preston Grasshoppers 5th XV | 24 | 19 | Preston Grasshoppers 6th XV |
| Saturday, 30 April 2022 |
| Aspull 3rd XV | Away Walkover | Garstang Blues (2nd XV) |
| Bolton 3rd XV | Home Walkover | Preston Grasshoppers 5th XV |