| Saturday, 3 September 2022 |
| Blackburn 3rd XV | 7 | 33 | Chorley |
| Eccles 2nd XV | 59 | 12 | Fylde Saracens (3rd XV) |
| Leigh 2nd XV | 38 | 21 | Southport 2nd XV |
| Preston Grasshoppers 3rd XV | 68 | 0 | Ormskirk 2nd XV |
| Saturday, 10 September 2022 |
| Chorley | 15 | 12 | Ormskirk 2nd XV |
| Fylde Saracens (3rd XV) | 71 | 17 | Kirkby Lonsdale RUFC Development XV |
| Southport 2nd XV | 22 | 29 | Preston Grasshoppers 3rd XV |
| Saturday, 17 September 2022 |
| Eccles 2nd XV | 54 | 10 | Blackburn 3rd XV |
| Kirkby Lonsdale RUFC Development XV | 22 | 17 | Aldwinians 2nd XV |
| Leigh 2nd XV | 12 | 54 | Fylde Saracens (3rd XV) |
| Ormskirk 2nd XV | 24 | 36 | Southport 2nd XV |
| Saturday, 24 September 2022 |
| Aldwinians 2nd XV | 36 | 19 | Leigh 2nd XV |
| Blackburn 3rd XV | 27 | 32 | Kirkby Lonsdale RUFC Development XV |
| Chorley | 22 | 19 | Southport 2nd XV |
| Fylde Saracens (3rd XV) | 24 | 17 | Preston Grasshoppers 3rd XV |
| Saturday, 1 October 2022 |
| Eccles 2nd XV | Home Walkover | Chorley |
| Leigh 2nd XV | 22 | 5 | Blackburn 3rd XV |
| Ormskirk 2nd XV | 15 | 49 | Fylde Saracens (3rd XV) |
| Preston Grasshoppers 3rd XV | 22 | 17 | Aldwinians 2nd XV |
| Saturday, 8 October 2022 |
| Aldwinians 2nd XV | 10 | 16 | Eccles 2nd XV |
| Saturday, 15 October 2022 |
| Aldwinians 2nd XV | 39 | 38 | Ormskirk 2nd XV |
| Blackburn 3rd XV | 14 | 32 | Preston Grasshoppers 3rd XV |
| Eccles 2nd XV | 55 | 5 | Kirkby Lonsdale RUFC Development XV |
| Fylde Saracens (3rd XV) | 45 | 17 | Southport 2nd XV |
| Saturday, 22 October 2022 |
| Kirkby Lonsdale RUFC Development XV | 5 | 42 | Chorley |
| Leigh 2nd XV | 0 | 38 | Eccles 2nd XV |
| Ormskirk 2nd XV | 55 | 17 | Blackburn 3rd XV |
| Southport 2nd XV | 27 | 24 | Aldwinians 2nd XV |
| Saturday, 29 October 2022 |
| Blackburn 3rd XV | 29 | 34 | Southport 2nd XV |
| Chorley | 6 | 28 | Fylde Saracens (3rd XV) |
| Eccles 2nd XV | 8 | 31 | Preston Grasshoppers 3rd XV |
| Kirkby Lonsdale RUFC Development XV | 41 | 17 | Leigh 2nd XV |
| Saturday, 5 November 2022 |
| Fylde Saracens (3rd XV) | 66 | 7 | Aldwinians 2nd XV |
| Kirkby Lonsdale RUFC Development XV | 7 | 36 | Preston Grasshoppers 3rd XV |
| Leigh 2nd XV | 0 | 57 | Chorley |
| Ormskirk 2nd XV | 17 | 17 | Eccles 2nd XV |
| Saturday, 12 November 2022 |
| Blackburn 3rd XV | 10 | 41 | Fylde Saracens (3rd XV) |
| Chorley | 40 | 8 | Aldwinians 2nd XV |
| Eccles 2nd XV | 50 | 10 | Southport 2nd XV |
| Kirkby Lonsdale RUFC Development XV | 15 | 32 | Ormskirk 2nd XV |
| Preston Grasshoppers 3rd XV | 82 | 0 | Leigh 2nd XV |
| Saturday, 26 November 2022 |
| Aldwinians 2nd XV | Home Walkover | Blackburn 3rd XV |
| Ormskirk 2nd XV | 71 | 0 | Leigh 2nd XV |
| Southport 2nd XV | Home Walkover | Kirkby Lonsdale RUFC Development XV |
| Saturday, 3 December 2022 |
| Eccles 2nd XV | 20 | 12 | Aldwinians 2nd XV |
| Kirkby Lonsdale RUFC Development XV | 7 | 19 | Fylde Saracens (3rd XV) |
| Ormskirk 2nd XV | 5 | 27 | Chorley |
| Preston Grasshoppers 3rd XV | 81 | 0 | Southport 2nd XV |
| Saturday, 17 December 2022 |
| Southport 2nd XV | 5 | 0 | Chorley |
| Saturday, 7 January 2023 |
| Aldwinians 2nd XV | 17 | 0 | Preston Grasshoppers 3rd XV |
| Blackburn 3rd XV | 57 | 7 | Leigh 2nd XV |
| Eccles 2nd XV | 12 | 17 | Chorley |
| Fylde Saracens (3rd XV) | 40 | 17 | Ormskirk 2nd XV |
| Saturday, 14 January 2023 |
| Kirkby Lonsdale RUFC Development XV | 0 | 17 | Eccles 2nd XV |
| Ormskirk 2nd XV | 15 | 28 | Aldwinians 2nd XV |
| Preston Grasshoppers 3rd XV | 39 | 5 | Blackburn 3rd XV |
| Southport 2nd XV | 7 | 36 | Fylde Saracens (3rd XV) |
| Saturday, 21 January 2023 |
| Chorley | 5 | 0 | Kirkby Lonsdale RUFC Development XV |
| Saturday, 28 January 2023 |
| Fylde Saracens (3rd XV) | 27 | 11 | Chorley |
| Leigh 2nd XV | 24 | 10 | Kirkby Lonsdale RUFC Development XV |
| Preston Grasshoppers 3rd XV | 23 | 5 | Eccles 2nd XV |
| Southport 2nd XV | 55 | 0 | Blackburn 3rd XV |
| Saturday, 4 February 2023 |
| Blackburn 3rd XV | 61 | 5 | Ormskirk 2nd XV |
| Chorley | 5 | 20 | Preston Grasshoppers 3rd XV |
| Leigh 2nd XV | 0 | 65 | Aldwinians 2nd XV |
| Saturday, 11 February 2023 |
| Aldwinians 2nd XV | 10 | 29 | Fylde Saracens (3rd XV) |
| Chorley | 42 | 0 | Leigh 2nd XV |
| Eccles 2nd XV | 87 | 5 | Ormskirk 2nd XV |
| Preston Grasshoppers 3rd XV | 63 | 10 | Kirkby Lonsdale RUFC Development XV |
| Saturday, 18 February 2023 |
| Aldwinians 2nd XV | 33 | 12 | Chorley |
| Fylde Saracens (3rd XV) | 59 | 0 | Blackburn 3rd XV |
| Leigh 2nd XV | 0 | 51 | Preston Grasshoppers 3rd XV |
| Ormskirk 2nd XV | Home Walkover | Kirkby Lonsdale RUFC Development XV |
| Southport 2nd XV | 10 | 55 | Eccles 2nd XV |
| Saturday, 25 February 2023 |
| Aldwinians 2nd XV | 55 | 12 | Southport 2nd XV |
| Eccles 2nd XV | 81 | 0 | Leigh 2nd XV |
| Kirkby Lonsdale RUFC Development XV | 7 | 31 | Blackburn 3rd XV |
| Preston Grasshoppers 3rd XV | Home Walkover | Chorley |
| Saturday, 4 March 2023 |
| Aldwinians 2nd XV | 20 | 10 | Blackburn 3rd XV |
| Leigh 2nd XV | 7 | 62 | Ormskirk 2nd XV |
| Preston Grasshoppers 3rd XV | 12 | 33 | Fylde Saracens (3rd XV) |
| Southport 2nd XV | Home Walkover | Kirkby Lonsdale RUFC Development XV |
| Saturday, 11 March 2023 |
| Chorley | 52 | 7 | Blackburn 3rd XV |
| Fylde Saracens (3rd XV) | 43 | 7 | Eccles 2nd XV |
| Ormskirk 2nd XV | 5 | 83 | Preston Grasshoppers 3rd XV |
| Southport 2nd XV | 61 | 17 | Leigh 2nd XV |
| Saturday, 18 March 2023 |
| Aldwinians 2nd XV | 41 | 21 | Kirkby Lonsdale RUFC Development XV |
| Blackburn 3rd XV | Away Walkover | Eccles 2nd XV |
| Fylde Saracens (3rd XV) | Home Walkover | Leigh 2nd XV |
| Southport 2nd XV | Home Walkover | Ormskirk 2nd XV |