| Saturday, 4 September 2021 |
| Broughton Park 3rd XV | 24 | 7 | Wythenshawe |
| Bury 3rd XV | 22 | 33 | Knutsford 2nd XV |
| Saturday, 11 September 2021 |
| North Manchester 2nd XV | 33 | 31 | Carrington |
| Wythenshawe | 19 | 46 | Heaton Moor 3rd XV |
| Saturday, 18 September 2021 |
| Broughton Park 3rd XV | 70 | 52 | North Manchester 2nd XV |
| Manchester Hawks | 24 | 36 | Wythenshawe |
| Saturday, 25 September 2021 |
| Carrington | Away Walkover | Bury 3rd XV |
| North Manchester 2nd XV | 52 | 40 | Heaton Moor 3rd XV |
| Saturday, 2 October 2021 |
| Broughton Park 3rd XV | 52 | 24 | Carrington |
| Knutsford 2nd XV | 20 | 14 | Wythenshawe |
| Saturday, 16 October 2021 |
| Broughton Park 3rd XV | 41 | 29 | Bury 3rd XV |
| Carrington | 21 | 31 | Heaton Moor 3rd XV |
| North Manchester 2nd XV | 74 | 5 | Newcastle (Staffs) 3rd XV |
| Saturday, 23 October 2021 |
| Heaton Moor 3rd XV | 12 | 61 | Broughton Park 3rd XV |
| Knutsford 2nd XV | Home Walkover | North Manchester 2nd XV |
| Manchester Hawks | 12 | 41 | Carrington |
| Saturday, 30 October 2021 |
| Broughton Park 3rd XV | 34 | 0 | Manchester Hawks |
| Heaton Moor 3rd XV | 17 | 57 | Bury 3rd XV |
| Saturday, 13 November 2021 |
| Knutsford 2nd XV | 46 | 17 | Carrington |
| Manchester Hawks | Away Walkover | Heaton Moor 3rd XV |
| Newcastle (Staffs) 3rd XV | 10 | 26 | Broughton Park 3rd XV |
| Wythenshawe | 15 | 5 | Bury 3rd XV |
| Saturday, 20 November 2021 |
| Broughton Park 3rd XV | 15 | 24 | Knutsford 2nd XV |
| Heaton Moor 3rd XV | Home Walkover | Newcastle (Staffs) 3rd XV |
| Manchester Hawks | 20 | 24 | Bury 3rd XV |
| Saturday, 27 November 2021 |
| Knutsford 2nd XV | 29 | 14 | Heaton Moor 3rd XV |
| Wythenshawe | 12 | 24 | North Manchester 2nd XV |
| Saturday, 4 December 2021 |
| Manchester Hawks | 21 | 62 | Knutsford 2nd XV |
| Newcastle (Staffs) 3rd XV | 33 | 22 | Bury 3rd XV |
| Saturday, 8 January 2022 |
| Wythenshawe | 12 | 17 | Manchester Hawks |
| Saturday, 15 January 2022 |
| Bury 3rd XV | 32 | 0 | Carrington |
| Heaton Moor 3rd XV | Away Walkover | North Manchester 2nd XV |
| Saturday, 22 January 2022 |
| Carrington | 17 | 41 | Broughton Park 3rd XV |
| North Manchester 2nd XV | Home Walkover | Manchester Hawks |
| Wythenshawe | Home Walkover | Knutsford 2nd XV |
| Saturday, 29 January 2022 |
| Bury 3rd XV | 17 | 27 | Broughton Park 3rd XV |
| Heaton Moor 3rd XV | 22 | 7 | Carrington |
| Saturday, 5 February 2022 |
| Newcastle (Staffs) 3rd XV | 38 | 8 | Manchester Hawks |
| Saturday, 12 February 2022 |
| Broughton Park 3rd XV | 43 | 5 | Heaton Moor 3rd XV |
| Carrington | 12 | 24 | Manchester Hawks |
| Knutsford 2nd XV | Home Walkover | North Manchester 2nd XV |
| Newcastle (Staffs) 3rd XV | 0 | 5 | Wythenshawe |
| Saturday, 19 February 2022 |
| Broughton Park 3rd XV | 36 | 12 | Manchester Hawks |
| Newcastle (Staffs) 3rd XV | 5 | 0 | Carrington |
| Saturday, 26 February 2022 |
| Bury 3rd XV | 7 | 32 | Heaton Moor 3rd XV |
| Carrington | 20 | 20 | Newcastle (Staffs) 3rd XV |
| North Manchester 2nd XV | 5 | 0 | Manchester Hawks |
| Saturday, 5 March 2022 |
| Broughton Park 3rd XV | 50 | 17 | Newcastle (Staffs) 3rd XV |
| Bury 3rd XV | 30 | 32 | Wythenshawe |
| Carrington | Home Walkover | Knutsford 2nd XV |
| Heaton Moor 3rd XV | 31 | 6 | Manchester Hawks |
| Saturday, 12 March 2022 |
| Bury 3rd XV | 12 | 21 | Manchester Hawks |
| Heaton Moor 3rd XV | 25 | 0 | Newcastle (Staffs) 3rd XV |
| Knutsford 2nd XV | 48 | 39 | Broughton Park 3rd XV |
| Wythenshawe | 30 | 10 | Carrington |
| Saturday, 19 March 2022 |
| North Manchester 2nd XV | Away Walkover | Broughton Park 3rd XV |
| Wythenshawe | 14 | 40 | Newcastle (Staffs) 3rd XV |
| Saturday, 26 March 2022 |
| Heaton Moor 3rd XV | Home Walkover | Knutsford 2nd XV |
| Manchester Hawks | 66 | 22 | Newcastle (Staffs) 3rd XV |
| North Manchester 2nd XV | 41 | 5 | Wythenshawe |
| Saturday, 2 April 2022 |
| Bury 3rd XV | 77 | 0 | Newcastle (Staffs) 3rd XV |
| Knutsford 2nd XV | 72 | 13 | Manchester Hawks |
| Saturday, 9 April 2022 |
| Bury 3rd XV | 51 | 36 | North Manchester 2nd XV |
| Bury 3rd XV | 51 | 36 | North Manchester 2nd XV |
| Carrington | 5 | 81 | Wythenshawe |
| Newcastle (Staffs) 3rd XV | 38 | 25 | Knutsford 2nd XV |
| Saturday, 23 April 2022 |
| Knutsford 2nd XV | 47 | 24 | Bury 3rd XV |
| Newcastle (Staffs) 3rd XV | 55 | 34 | North Manchester 2nd XV |
| Wythenshawe | 69 | 12 | Broughton Park 3rd XV |
| Saturday, 30 April 2022 |
| Carrington | Away Walkover | North Manchester 2nd XV |
| Heaton Moor 3rd XV | 65 | 7 | Wythenshawe |
| Knutsford 2nd XV | 12 | 52 | Newcastle (Staffs) 3rd XV |