| Round 1 |
| Saturday, 1 November 2025 |
| 1 | Aldwinians 3rd XV | v | East Manchester RUFC 1st XV Men |
| 2 | Aspull 3rd XV | v | Winner Oldershaw v Prenton |
| 3 | Winner Manchester 3 v Old Beds | v | Southport 3rd XV |
| 4 | Knutsford | v | Dukinfield 2nd XV |
| 5 | Ormskirk 2nd XV | v | Winner Clitheroe 2 v Tyldesley 2 |
| 6 | Winner Wigan 3 v Fleetwood 2 | v | Winnington Park 3rd XV |
| 7 | Mossley Hill | v | Winner Garstang 3 v Leigh 2 |
| 8 | Winner Helsby v Anselmians 3 | v | Rochdale 3rd XV |
| Round 2 |
| Saturday, 7 February 2026 |
| Winner of Match 1 | v | Winner of Match 2 |
| Winner of Match 3 | v | Winner of Match 4 |
| Winner of Match 5 | v | Winner of Match 6 |
| Winner of Match 7 | v | Winner of Match 8 |
| Round 3 |
| Saturday, 14 March 2026 |
| TBC | v | TBC |
| TBC | v | TBC |
| Round 4 |
| Saturday, 2 May 2026 |
| TBC | v | TBC |